Yazarlar : Talbot NP, Lakhal S, Smith TG, Privat C, Nickol AH, Rivera-Ch M, León-Velarde F, Dorrington KL, Mole DR, Robbins PA.

Yayın : Blood.

Yayın Yılı : 2011

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22130801

Konu : Diğer

Literatür İçeriği :  

Abstract

Enhanced erythropoietic drive and iron deficiency both influence iron homeostasis through suppression of the iron regulatory hormone hepcidin. Hypoxia also suppresses hepcidin through a mechanism that is unknown. We measured iron indices and plasma hepcidin levels in healthy volunteers during a 7-day sojourn to high altitude (4340 m above sea level), with and without prior intravenous iron loading. Without prior iron loading, a rapid reduction in plasma hepcidin was observed that was almost complete by the second day at altitude. This occurred before any index of iron availability had changed. Prior iron loading delayed the fall in hepcidin until after the transferrin saturation, but not the ferritin concentration, had normalised. We conclude that hepcidin suppression by the hypoxia of high altitude is not driven by a reduction in iron stores.

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