Yazarlar : Cheah C, Hofman M, Seymour J

Yayın : Leuk Lymphoma

Yayın Yılı : 2014

Pubmed Linki : http://www.docguide.com/utility-and-limitations-pet-ct-patients-primary-mediastinal-b-cell-lymphoma-single-institution-exper?tsid=5

Konu : Lenfoma

Literatür İçeriği :  Abstract There are limited data regarding role of PET-CT scanning in primary mediastinal B-cell lymphoma (PMBL). We analyzed 28 patients with PMBL treated with chemotherapy, of whom 25 (89%) also received rituximab and 17 (61%) radiotherapy. PET-CT scans were interpreted using visual analysis and 5-point scale. After median follow up of 2.6 years, four patients relapsed and two died. The 2-year progression-free survival (PFS) and overall survival were 86% and 94%. PET-CT has excellent negative predictive value (interim, 86-87%; end of treatment, 95%) but limited positive predictive value due to the high frequency of positive scans. Several patients with persistent metabolically active masses underwent biopsies, which showed necrosis but no lymphoma. Thus a negative PET-CT is an excellent predictor of subsequent outcome, however residual metabolically active masses after treatment should be biopsied to confirm viable lymphoma prior to salvage therapy.

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